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Home > STEM Learning Journeys > DNA: The Building Blocks — Intermediate Lessons Bundle

Lesson 2: DNA Mutations in Action

A stylized white DNA double helix made of dots appears along the left edge of a blue background with a subtle grid pattern, leaving ample blank space on the right.

Prepare for lesson:

  1. Review video
  2. Either prepare a sample bracelet that follows a specific DNA sequence OR have a DNA code template ready to share with the  class
  3. Supplies:
    1. Multicolored beads (handful per youth)
    2. String enough for each youth

During the lesson:

Activity 1

  1. Place youth in small groups, give them one of the 6 types of DNA mutation and have them describe the mutation to the class without words (they can choose to draw or mime it in their groups).
  2. The class gets to guess the type of mutation.
  3. For a challenge, have youth share their guesses after each group has gone.

Activity 2

  1. Show the class a sample bracelet of at least 20 beads (or a written sequence of bead colors) and give them 15 seconds to memorize the sequence.
  2. Have youth make bracelets replicating the sequence
  3. Have small groups compare their bracelets
  4. Have youth share out, what mutations were made? Tally the numbers. Is there a more popular mutation? Why do they think so?